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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c53b3372e8e8cc06370c386e7354b7f59232e88a1438f902430f32b77cbc6ad' 
  AND token = 'LDpyuMSSRsqlZCvatNaZ/MAS6/d8fuAC0mp/LEEXJlg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}