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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49bfac4fab6f700ec3b36666f106fe148b1b6b57a7c90a48f7925f14131fd893' 
  AND token = 'OK180XsBZ3QUwEclr7Wlz3BnsDLRWc/8ahyNoFVAJwU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}