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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '166f0dc640f2e8137f62de5ab3e02ac6e348b1ca41383d1f34451d2058f11554' 
  AND token = 'TihGZN1+tAZPWxcxC2c/WNXbrEGxF1RUAUcSARtWwfA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}