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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59a0d94df0acaddf2c353741d7f93c17c1b970e824b4b9042c289079a2a63a0f' 
  AND token = 'p9piXtkGX8iPzSW9h2sl8+wAUVD8GRMP6BfeiCzHzPY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}