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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e078b7e659e2f68511414c5794c68657d39cff6a1ff37d31d3ac2cfe4540a27' 
  AND token = 'SFlIqSfEVxgypRgecf6k1yo8G8vU4aGT505y7QCyNx0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}