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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59d578d8d0551711f76a9c484a953f061e3b81f25b2396c2b3986fc5e3a325de' 
  AND token = 'lQsi6rFc9PErRH9b8s5yv+BYbJWGnBvW6FAGl0RHQmY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}