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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b540dfc02414402e9aa7c51c50cd608666e1c1efbcb8fc960ec64450ccead959' 
  AND token = 'O8ISWUwpgMmLxXdh3s4/E43makeBvwB9JsoMfo9oLcg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}