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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4ae01d6b8864cddc07a99a67c8888737948224db6dd4102ca61be42fada2a4bb' 
  AND token = 'dsks5VM64ll7J6FYd5p+hyNAYR/wfq6Z65gBcLVFTX0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}