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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '273aa65521d7b4a72c905712ecef68f8b3b1d16789d6fe0156f66ae6a936c66a' 
  AND token = 'mE5Dr5XsBqgy4PQrFTjopYdrPBBBcD+GxwZ8p3tBUg4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}