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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22451f89f22e9b0a8ecc40ed050a2fcb6e81227d09baa937ff068a4d0474237f' 
  AND token = 'Tk/5VxCsG6LTv88Q2Z2Laq3MEefRdHPxSaS4JFNStXU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}