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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78aa5df808002fb7e4258a8168795ece694058c704ad843aa7d2cc48571f3390' 
  AND token = '1nBsfmCyeEMArlTUFbxcn2GWtVmyCVZmS8w2N8IeCmc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}