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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0d70e1de496b9c779f3881d4f4365c801280b229dbdcfa93c2d3dca52fbfefaf' 
  AND token = 'MEEM+Zo0+gMfnnRkuIRWFJDBm3QvxQK+I2xTzvsRkVs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}