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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c0f3455aaebaf095f867bbfcddf45f15d908a96c78e167b21c924f63a0ce9e8' 
  AND token = '1VD/UAoI+AQM3uNg2P9a1b3U1s4MU6lNHBeznGSZ4Hk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}