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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de37048e09327aaab1e5f459e3dd4bce3743c3fa5440404219b996f79f3796ef' 
  AND token = 'CZ7A4HlMe44E/9VSV9a09RkKEjMvTqCjcYtEOjnEWdY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}