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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f221f670b848a207e0a28e13baedfa1c5c9f0b5d55e498fd4e3262a408abf1c3' 
  AND token = 'jPmRYpLcCcAtXYjBzBjwnz7pWyhQhizkUhNkmW8Uwt4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}