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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e8a7cc0ebe678e3f66eeaf2c01d278df12912f01fb7b065f1d42f1e3a780273' 
  AND token = 'RAe+wfXzO+A6WnpnBYVo5f6CM89zs23omOTM7ouMfto=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}