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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50250bdc8a3897e1b2cae072e8094e8b3b41e9b3548a41a98df27970209822a7' 
  AND token = 'Dd9ExLFNubxpFi2wo5UT1EHGeK820teQo+3wmb7/rMI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}