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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45a6e876b474503c2c1bc64e4f19c2f217647d297117516bf0297c61a2ac041d' 
  AND token = 'tS3wXGG9nPlRIC6h0lvp2+6gPk0fELuEhmYmbiRRJEI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}