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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '800c57681c4d012c2e205c24734c13e1123df7c01ca2dec5ae54a110308a1254' 
  AND token = 'gEVy/Z2aZ+z0f4OU7neJtdyk/b/svKpsCRHH+KsqjFw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}