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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3d7abdfcd29e6685f97f404039c9056a7967a8185384b93660a9119ed351ad05' 
  AND token = 'eRvBzxf+8ojyxvMxRxIr5Qe6mp1ULcPj4BwWcYtkIzI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}