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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6f0d1a433e73e4e5bf7e402e1646370c26aea04a023bb0a025d37a86e90b1e7f' 
  AND token = '+RXb2WZUshsUXy/K+AoSUoUUDFiT1p+qpbVyNpFOMdE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}