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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '88e1d91eb65d5c7821b2c34166ab8bdd37bee15e4caf063c4f3b1002af703ec8' 
  AND token = 'HCvLDeh575pLm0ZoGNaSTOUqmdtSwQRsBIdWzzmPbI8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}