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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42de4bee89aa26ac5fb7b91d3bedfccb7a59e5301cb7f8d05b8c1f355b7eab52' 
  AND token = 'JQO6X3ZxpFQekhMNOD/LLzHire6xmdrExPz0O8raNwc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}