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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45d690a50b7280e98f69fe05840c4adc19090d7dfa1820f2e5d5506fbf305995' 
  AND token = 'UPYhze6Li1UjmfurljmmdeMKMVMWbKNplen1+XuAIcs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}