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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22c3d4b305bf115a536e8fa935ea91826b5dc762ec30727f228c500bca26b43c' 
  AND token = 'yr0va/UmHrmnyWbmuAD1JT+KgtR6ptYU3cUvEySH8FQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00065

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}