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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e6dca1645a19bfb8d4ec55725c2fb01826513e4fb9de8e47518a7be62fa8663' 
  AND token = 'yV1RQpyWPmB1jSAMWDn/yHqebcwdLdGrWHPrqKTUXOs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}