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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21d288995c1e727dd23e600c7fb3d50ada7561789560bb7c029b26fc42cb16f0' 
  AND token = 'oBVZlP2AbMjevlXQ+lvUN+YYa4t9cBs+s8NWfC6eDPM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}