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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21e936a2257ba64eb2883e665a674aaf55b61270ffe3aa56b81b72865cdd419c' 
  AND token = 'E5uL3+x6WEIKAc2w2CzietnxI0i6PpFfc1wN+rwWvBQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}