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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '500e8f3b132be8397a4cc15c45caff8114de36eb61e66ec6c0420af8e0adfc03' 
  AND token = 'm2nMxs7I+MTXkyPIre66RH00iMCI1Z6UOOfyvfK+4xM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}