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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b0d7187f0caf845409adfff67e004ad67bfddde47c9fa615ecde5aeb332ea32' 
  AND token = '8XOk4fj4qkiEXd1ZsOgaQSoIFrVOgj2dITuLd8XKtRI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}