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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78091f7b8f4a688302dc48d77aa6f8aacdc738412f11fb6147b355e79b984070' 
  AND token = 'FT3mLsWnytrodOIPkcjCq/vWPWfLCfQ1NceLmpWTUMc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}