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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b5c8255435ab62299423360c78a2b9954521e484bd8856c81f08f94355116431' 
  AND token = 'meCRN3d/Gguv2ONKMvcaSm7pz/Hf65HuYEChfTUBMEY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}