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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cb3e8c1a18defa17456d2a1f363345711b92e2af23663abb0cb51da23be29a21' 
  AND token = 'rp7TS5z9GTsP4noeuBfA/iu9B9qBQjwRlALL+1Gg4RI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}