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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ca728b0fee04b59e68b5a488ec710ed10c99118e205ff3297103d032b673215b' 
  AND token = '9cfWTd8gVZSWiUbaRGF0Eo7W2xG8eBg5Aa20KYY4np4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}