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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45aab738cde3d4d5f06c3cd2eb51c21cdf660d9996b8f5ca2341305249bdb777' 
  AND token = 'I4RZD8SKoOZEO720MTy+OOBdiWwiyxdSFkqdVI00zxg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}