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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e386fde3060cfc8a03742700bb4f356b4e0476e8e1792ff75f88e016a1db0e59' 
  AND token = 'mXnB8mVnCQa+v8liKaMuGmTGtl3kCSs+I729qb1IjVA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}