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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e27045d1d2dc27742b77024f4420fa48007e0f3900b2353b7c060f2b3666224' 
  AND token = 'InAqevCwifddo3OAIOEEyU6SCPQPa4UtWku0KN17Jvw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}