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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '489ff5e1eafb8e7cdcbc16f778e6b22d7023b77b8b8d39333dc9cd5cb2ae2115' 
  AND token = 'SHfr/hrmQXcCGTp5CuRujb5VCrWr8vG0oy8US77LHpM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}