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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '521f025067825ce76379c3b3edfe1bf01c7e11269d0488b67f95d528a5d4a2b6' 
  AND token = '4pUJNcDP5Tispp9EjAt4s4j+hZ+xtaVULz9l1RRxbBM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}