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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '162104e81ed5f04ed3918b36939c06b775db70d8144fa8b8f1a8b07d7b7ce741' 
  AND token = 'kTU4kHgbjH3cQfab5AgMTNXCa1f1GvoBqMtR0ZC5juo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}