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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8fc7ee6d4edd68e31749a20895b057f0a644d79dc5eb6edd0aa6ddb2d7325c08' 
  AND token = 'Lt9X1t/uCzFJ0myH1soClLkg1nCXLP2UzLOpR8xwCAg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}