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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd4e526f00475375e22a4343fdc0cd300da2dfda25ff48c007e70c87cc1eaf4ce' 
  AND token = 'jrmf6/FoKfjN6BVi7i+tlWYZrIRYErC5jhtXu5x/twg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}