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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7c89fde7a6caa7c006ed9c680c8739368153af5b8e8fd9b28d76baa9ce166b34' 
  AND token = 'kDKmF01BjgFQHGGiPpkSyQBuWh7Ii3a9lvIOTGAWVRk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}