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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8843001f5392a8eb2bd89091aeba7402f8f1d2c1aca5491cae4414f61624bb15' 
  AND token = 'A4qDUB/+3No5nFapm3nN/yu78SnBbUjfKTMBh5GfWRY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}