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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f7c166f01fdb9fbdbaa2fa5b395a2eb66f4605925fbde20a7f1f28890184cadd' 
  AND token = 'q7nc/7JghQ8+fG5We6BVr3zz71D2mi0y9Z6fgTt6+gI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}