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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '272b2e9a7bff9d6ec472efcaf6f965ffef6e3655f61ef6aae7bcf492c4eaa665' 
  AND token = 'Ab/SYwLgCFm+h+Uul//7WCzEQ+g2uns5Ni5NiZSxW4M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}