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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c3301e1c836eb552ab91c17f38e487fb422fae7643cd379ff2e6644e7cb32ea' 
  AND token = '//srkXKl2xnJX+C4E386nmtWlsC5YbFy5fKTKEblJTU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}