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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '434188bb19bb5920c36b689002ef66a97aee552abcaac00af07442e74a573a69' 
  AND token = '0pGJ4w0SJYQAtmN7o6NkHGgNV0ZgSN7rH9r25bnWGSk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00058

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}