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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46c0becdaf50c6247f08ee48cd2c24b2b69ceb8f6af2af112543283cce57b646' 
  AND token = 'FZZUJ6QYYd3GH6QGILWEm7m8Skw3NBOiKftlB3Ynchc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}