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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4acaa6c1de8dcf60c811b6d79beece76aa8548d8f697488636e1869a7f3fb067' 
  AND token = 'QDObBB0hrLZlC9x0zMAPeAku2loUnxU2Jc7U94DE6KA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}